1,2,3-Trimethylbenzene (Hemellitene) 98% / 99% CAS No. 526-73-8 Industrial & Pharmaceutical Grade

1,2,3-Trimethylbenzene, available in 98% and 99% concentrations, is produced via advanced fractionation and purification technologies from petroleum refining streams or coal tar distillation. It features excellent solvency power, moderate volatility, and exceptional chemical stability as a trimethyl-substituted aromatic hydrocarbon. As an important organic intermediate, it is widely used in pharmaceutical synthesis, dye manufacturing, and specialty chemical production. Its high purity and consistent isomer composition make it ideal for critical applications requiring precise chemical properties. Each batch is rigorously tested using GC analysis to ensure consistent quality meeting industrial and pharmaceutical standards.

Scope of Application

Used as a key intermediate in pharmaceutical synthesis for producing anti-inflammatory drugs, platelet aggregation inhibitors, and thrombosis inhibitors through reaction with benzoyl chloride or phenylacetyl chloride ;
Acts as a raw material for the synthesis of musk fragrances and other specialty aroma chemicals ;
Functions as an intermediate in the production of dyes, pigments, and organic colorants ;
Widely applied in the manufacture of alkyd resins, polyester resins, and trimellitic acid derivatives ;
Serves as a laboratory solvent and reagent for organic synthesis and analytical chemistry;
Used in the production of plasticizers, epoxy resin curing agents, and surface-active agents;
Acts as a high-boiling solvent in specialty coating formulations;
Functions as a reference standard and calibration material in analytical chemistry for aromatic hydrocarbon analysis.

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Product Features

1,2,3-Trimethylbenzene is manufactured using advanced fractionation and purification technologies, ensuring consistent quality and precise isomer control. The product features excellent solvency for aromatic and non-polar compounds, with a boiling point of 175-176°C providing optimal processing characteristics . Its molecular weight of 120.19 and specific gravity of 0.894 at 20°C offer predictable handling properties . The product exhibits complete miscibility with ethanol, ether, benzene, acetone, petroleum ether, and carbon tetrachloride, while being practically insoluble in water . Available in multiple purity grades including 98% and 99% to suit different application requirements, from industrial synthesis to pharmaceutical manufacturing.

Packaging and Transportation

Available in epoxy-lined steel drums (160kg-180kg), IBC totes, and ISO tanks;

Classified as flammable liquid (Class 3), comply with all transportation safety regulations including UN3295 classification with Packing Group III ;

Safety and Storage

Store in a cool, well-ventilated warehouse away from kindling, heat sources, and direct sunlight ;

Maintain storage temperature below 30°C in a dry environment;

Keep containers tightly sealed to prevent evaporation and contamination;

Avoid storage with strong oxidizing agents, nitric acid, or halogens as violent reactions may occur ;

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FAQ

What are the primary pharmaceutical applications of 1,2,3-Trimethylbenzene?

1,2,3-Trimethylbenzene serves as an important intermediate in pharmaceutical synthesis. It can react with benzoyl chloride or phenylacetyl chloride to produce anti-inflammatory agents, platelet aggregation inhibitors, and thrombosis inhibitors . It is also used in the synthesis of various other therapeutic compounds where the trimethylphenyl moiety is required.

How does 1,2,3-Trimethylbenzene compare to its isomers (1,2,4- and 1,3,5-trimethylbenzene)?

The three trimethylbenzene isomers differ in the positions of the methyl groups on the benzene ring, which affects their physical properties and reactivity. 1,2,3-Trimethylbenzene (hemellitene) has the highest boiling point (176°C) compared to 1,2,4- (168°C) and 1,3,5- (164°C) isomers. It also exhibits unique reactivity patterns in electrophilic substitution due to the adjacent methyl groups. Each isomer finds different applications based on these property differences .

What safety precautions are essential when handling 1,2,3-Trimethylbenzene?

Due to its flammability (flash point 48°C) and potential health effects, essential precautions include: adequate ventilation to minimize vapor inhalation, elimination of ignition sources, grounding containers during transfer to prevent static discharge, and appropriate PPE including chemical-resistant gloves and safety goggles . The vapor is heavier than air and may travel to ignition sources, so special care is needed in low-lying areas. Respiratory protection should be used when ventilation is inadequate. Eye wash stations and safety showers should be readily available in handling areas .